I use an Easy Digi interface between my Icom IC-2300, Direwolf & APRX. Here is my PTT string for my direwolf.conf file for Push To Talk:

DEVICE  plughw:1,0
ACHANNELS 1
CHANNEL 0

MYCALL MERIDN

MODEM 1200

#IC-2300
PTT /dev/ttyUSB0 DTR RTS

AGWPORT 8000
KISSPORT 8001

FIX_BITS 0
LOGDIR  /var/log/direwolf/